I don’t understand why Will Wheaton considers both Google AdSense and Federated Media as jokes for not being able to sell his ad space for more than a couple hundred a month.
Consider his ads were
laregly irrelevant due to the nature of his site
tucked away in the right side bar
on a tech blog where nobody clicks
If you want to sell brand ads sell them yourself, or create your own product to sell. If you are selling anything else you have to integrate them into your site. I have seen a CTR in excess of 10% off a single Google AdLinks unit. Those ads were targeted, aggressively integrated, and commercially oriented. That ad unit suffered from none of the faults of Will’s ad model.